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However, the current GSA11 tools utilize over representation analysis,12 which reports the enrichment of functional groups (for example, gene sets) for the genes of interest. They compromise the connectivity in favor of computational simplicity that is based on cellular components and not their connectivity.3,4 In other words, current tools do not analyze the wiring diagram of the interactions (for example, activation, inhibition) in a functional molecular network.13We have developed PATHOME (pathway and transcriptome information), a novel computational algorithm for identifying differentially expressed subpathways.
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It was something really nice and really special, because you don't see that at any other college. That was a bonus right there. Lehnardt told her sponsor she allowed the teens to smoke pot and drink booze in her home. The mother also joined the group in a game of naked Twister.
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